abstract：:Growth factors acting through receptor tyrosine kinases (RTKs) of ERBB family, along with steroid hormones (SH) acting through nuclear receptors (NRs), are critical signalling mediators of cellular processes. Deregulations of ERBB and steroid hormone receptors are responsible for several diseases, including cancer, th...

journal_title：Seminars in cell & developmental biology

authors： D'Uva G,Lauriola M

更新日期：2016-02-01 00:00:00

abstract：:With computation models playing an ever increasing role in the advancement of science, it is important that researchers understand what it means to model something; recognize the implications of the conceptual, mathematical and algorithmic steps of model construction; and comprehend what models can and cannot do. Here...

journal_title：Seminars in cell & developmental biology

authors： Brodland GW

更新日期：2015-12-01 00:00:00

abstract：:Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are mak...

journal_title：Seminars in cell & developmental biology

authors： Saiz N,Plusa B,Hadjantonakis AK

更新日期：2015-12-01 00:00:00

abstract：:The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under...

journal_title：Seminars in cell & developmental biology

authors： Biggins JS,Royer C,Watanabe T,Srinivas S

更新日期：2015-12-01 00:00:00

abstract：:In the recent years several papers and some reviews have dealt with characterization, localization and influence on the precipitation of calcium carbonate, of the organic matrix from scleractinian corals. In fact, it has been well established that coral calcification is a biological controlled process orchestrated in ...

journal_title：Seminars in cell & developmental biology

authors： Falini G,Fermani S,Goffredo S

更新日期：2015-10-01 00:00:00

abstract：:The wide diversity of biogenic minerals that is found in nature, each with its own morphology, mechanical properties and composition, is remarkable. In order to produce minerals that are optimally adapted for their function, biomineralisation usually occurs under strict cellular control. This control is exerted by spe...

journal_title：Seminars in cell & developmental biology

authors： Nudelman F

更新日期：2015-10-01 00:00:00

abstract：:Mature skeletal muscle forms from the fusion of skeletal muscle precursor cells, myoblasts. Myoblasts fuse to other myoblasts to generate multinucleate myotubes during myogenesis, and myoblasts also fuse to other myotubes during muscle growth and repair. Proteins within myoblasts and myotubes regulate complex processe...

journal_title：Seminars in cell & developmental biology

authors： Demonbreun AR,Biersmith BH,McNally EM

更新日期：2015-09-01 00:00:00

abstract：:The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germl...

journal_title：Seminars in cell & developmental biology

authors： Young JC,Wakitani S,Loveland KL

更新日期：2015-09-01 00:00:00

abstract：:Paramutation was initially described in maize and was defined as an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification of the other allele without modifying the DNA sequence [1,2]. Thus it implies that the paramutated allele conserves its new properties on ...

journal_title：Seminars in cell & developmental biology

authors： Ronsseray S

更新日期：2015-08-01 00:00:00

abstract：:Increasing evidence has highlighted the critical role of early life environment in shaping the future health outcomes of an individual. Moreover, recent studies have revealed that early life perturbations can affect the health of subsequent generations. Hypothesized mechanisms of multi- and transgenerational inheritan...

journal_title：Seminars in cell & developmental biology

authors： Xin F,Susiarjo M,Bartolomei MS

更新日期：2015-07-01 00:00:00

abstract：:It is now well established that the environment to which we are exposed during fetal and neonatal life can have a long-term impact on our health. This has been termed the developmental origins of health and disease. Factors known to have such programming effects include intrauterine nutrient availability (determined b...

journal_title：Seminars in cell & developmental biology

authors： Fernandez-Twinn DS,Constância M,Ozanne SE

更新日期：2015-07-01 00:00:00

abstract：:IgE-mediated food allergy is a developing global health problem with prevalence rising at alarmingly fast rates. In this review, we discuss the interplay between genetics, epigenetics, and environmental exposures in the pathogenesis of food allergies. We aim to highlight the most recent evidence that suggests how epig...

journal_title：Seminars in cell & developmental biology

authors： Quake C,Nadeau KC

更新日期：2015-07-01 00:00:00

abstract：:During the course of their classic experiments, Hilde Mangold and Hans Spemann discovered that the dorsal blastopore lip of an amphibian gastrula was able to induce formation of a complete embryonic axis when transplanted into the ventral side of a host gastrula embryo. Since then, the inducing activity of the dorsal ...

journal_title：Seminars in cell & developmental biology

authors： Thisse B,Thisse C

更新日期：2015-06-01 00:00:00

abstract：:The role of the tight junctions (TJ) in controlling paracellular traffic of ions and molecules, through the regulation of claudin proteins, is now established. However, it has also become increasingly evident that claudin proteins, as integral components of the TJs, play crucial role in maintaining the cell-cell integ...

journal_title：Seminars in cell & developmental biology

authors： Singh AB,Dhawan P

更新日期：2015-06-01 00:00:00

abstract：:The members of the large family of claudin proteins regulate ion and water flux across the tight junction. Many claudins, e.g. claudins 2 and 15, accomplish this by forming size- and charge-selective paracellular channels. Claudins also appear to be essential for genesis of tight junction strands and recruitment of ot...

journal_title：Seminars in cell & developmental biology

authors： Lingaraju A,Long TM,Wang Y,Austin JR 2nd,Turner JR

更新日期：2015-06-01 00:00:00

abstract：:The immune system consists of a heterogeneous ensemble of cell types that immunologists have tried to classify and order for decades. This classification has relied on varying criteria, resulting in major debates in the immunology community. Discovered in the late 1970s [1], dendritic cells (DCs) are no exception, and...

journal_title：Seminars in cell & developmental biology

authors： Perié L,Naik SH

更新日期：2015-05-01 00:00:00

abstract：:For cell-to-cell communication, all living cells including archaea, bacteria, and eukaryotes secrete nano-sized membrane vesicles into the extracellular space. These extracellular vesicles harbor specific subsets of proteins, mRNAs, miRNAs, lipids, and metabolites that represent their cellular status. These vesicle-sp...

journal_title：Seminars in cell & developmental biology

authors： Kim DK,Lee J,Simpson RJ,Lötvall J,Gho YS

更新日期：2015-04-01 00:00:00

abstract：:Extracellular vesicles (EVs) act as carriers of molecular and oncogenic signatures present in subsets of tumour cells and tumour-associated stroma, and as mediators of intercellular communication. These processes likely involve cancer stem cells (CSCs). EVs represent a unique pathway of cellular export and cell-to-cel...

journal_title：Seminars in cell & developmental biology

authors： Nakano I,Garnier D,Minata M,Rak J

更新日期：2015-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares, which causes swelling, pain, and irreversible connective tissue damage. Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it "expands" in size and...

journal_title：Seminars in cell & developmental biology

authors： Bouta EM,Li J,Ju Y,Brown EB,Ritchlin CT,Xing L,Schwarz EM

更新日期：2015-02-01 00:00:00

abstract：:Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide. Due to its critical role in the process of inflammation, a dysfunctional lymphatic system also compromises the immune response, further exacerbating a number of inflammation related diseases. Despite the c...

journal_title：Seminars in cell & developmental biology

authors： Chakraborty S,Davis MJ,Muthuchamy M

更新日期：2015-02-01 00:00:00

abstract：:Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-da...

journal_title：Seminars in cell & developmental biology

authors： Serlin Y,Shelef I,Knyazer B,Friedman A

更新日期：2015-02-01 00:00:00

abstract：:A substantial fraction of the human proteome encodes disordered proteins. Protein disorder is associated with a variety of cellular functions and misfunction, and is therefore of clear import to biological systems. However, disorder lends itself to conformational flexibility and heterogeneity, rendering proteins which...

journal_title：Seminars in cell & developmental biology

authors： Lee T,Moran-Gutierrez CR,Deniz AA

更新日期：2015-01-01 00:00:00

abstract：:The functional unit of the mammalian metanephric kidney is the nephron: a complex tubular structure dedicated to blood filtration and maintenance of several important physiological functions. Nephrons are assembled from a nephron-restricted pool of mesenchymal progenitors over an extensive developmental period that is...

journal_title：Seminars in cell & developmental biology

authors： O'Brien LL,McMahon AP

更新日期：2014-12-01 00:00:00

abstract：:Control of translation allows for the production of stoichiometric levels of each protein in the cell. Attaining such a level of fine-tuned regulation of protein production requires the coordinated temporal and spatial control of numerous cellular signalling cascades impinging on the various components of the translat...

journal_title：Seminars in cell & developmental biology

authors： Fonseca BD,Smith EM,Yelle N,Alain T,Bushell M,Pause A

更新日期：2014-12-01 00:00:00

abstract：:The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of ...

journal_title：Seminars in cell & developmental biology

authors： Larre I,Ponce A,Franco M,Cereijido M

更新日期：2014-12-01 00:00:00

abstract：:The question of how the physical dimensions of animal organs are specified has long fascinated both experimentalists and computational scientists working in the field of developmental biology. Research over the last few decades has identified many of the genes and signaling pathways involved in organizing the emergent...

journal_title：Seminars in cell & developmental biology

authors： Buchmann A,Alber M,Zartman JJ

更新日期：2014-11-01 00:00:00

abstract：:Axonal projections between two populations of neurons, which preserve neighborhood relationships, are called topographic. They are ubiquitous in the brain. The development of the retinotectal projection, mapping the retinal output onto the roof of the midbrain, has been studied for decades as a model system. The rigid...

journal_title：Seminars in cell & developmental biology

authors： Weth F,Fiederling F,Gebhardt C,Bastmeyer M

更新日期：2014-11-01 00:00:00

abstract：:Cell motility is a tightly regulated process that involves the polymerization of actin subunits. The formation of actin filaments is controlled through a variety of protein factors that accelerate or perturb the polymerization process. As is the case for most biological events, cell movement is also controlled at the ...

journal_title：Seminars in cell & developmental biology

authors： Artman L,Dormoy-Raclet V,von Roretz C,Gallouzi IE

更新日期：2014-10-01 00:00:00

abstract：:The retrograde trafficking from endosomes to the trans-Golgi network (TGN) is one of the major endocytic pathways to divert proteins and lipids away from lysosomal degradation. Retrograde transported cargos enter the TGN via two itineraries from either the early endosome/recycling endosome or the late endosome and inv...

journal_title：Seminars in cell & developmental biology

authors： Lu L,Hong W

更新日期：2014-07-01 00:00:00

abstract：:Any type of tubulogenesis is a process that is highly coordinated between large numbers of cells. Like other morphogenetic processes, it is driven to a great extent by complex cell shape changes and cell rearrangements. The formation of the salivary glands in the fly embryo provides an ideal model system to study thes...

journal_title：Seminars in cell & developmental biology

authors： Girdler GC,Röper K

更新日期：2014-07-01 00:00:00

abstract：:When studying the living endosome one must first recognise that we are not studying a single discrete organelle but rather a highly dynamic interconnected network of membrane-bound compartments. Endocytosed molecules are sorted and transported through various polymorphic intracellular organelles that mature and intera...

journal_title：Seminars in cell & developmental biology

authors： Kerr M,Teasdale RD

更新日期：2014-07-01 00:00:00

abstract：:The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membra...

journal_title：Seminars in cell & developmental biology

authors： Granger E,McNee G,Allan V,Woodman P

更新日期：2014-07-01 00:00:00

abstract：:In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a family of peptide growth factors that activate the EGF receptors, and that the EGF/EGF receptor signaling pathway plays important roles in...

journal_title：Seminars in cell & developmental biology

authors： Zeng F,Harris RC

更新日期：2014-04-01 00:00:00

abstract：:Given the large socio-economic burden of cancer, there is an urgent need for in vivo animal cancer models that can provide a rationale for personalised therapeutic regimens that are translatable to the clinic. Recent developments in establishing mouse models that closely resemble human lung cancers involve the applica...

journal_title：Seminars in cell & developmental biology

authors： Hayes SA,Hudson AL,Clarke SJ,Molloy MP,Howell VM

更新日期：2014-03-01 00:00:00

abstract：:Four conserved signaling pathways, including the bone morphogenetic proteins (Bmp), fibroblast growth factors (Fgf), sonic hedgehog (Shh), and wingless-related (Wnt) pathways, are each repeatedly used throughout tooth development. Inactivation of any of these resulted in early tooth developmental arrest in mice. The m...

journal_title：Seminars in cell & developmental biology

authors： Lan Y,Jia S,Jiang R

更新日期：2014-01-01 00:00:00

abstract：:Cichlid fishes constitute one of the most species-rich families of vertebrates. In addition to complex social behaviour and morphological versatility, they are characterised by extensive diversity in colouration, both within and between species. Here, we review the cellular and molecular mechanisms underlying colour v...

journal_title：Seminars in cell & developmental biology

authors： Maan ME,Sefc KM

更新日期：2013-06-01 00:00:00

abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...

journal_title：Seminars in cell & developmental biology

authors： Lopez-Vernaza MA,Leach DR

更新日期：2013-05-18 00:00:00

abstract：:Wnt signaling is a hallmark of all embryonic development with multiple roles at multiple developmental time points. Wnt signaling is also important in the development of several organs, one of which is the inner ear, where it participates in otic specification, the formation of vestibular structures, and the developme...

journal_title：Seminars in cell & developmental biology

authors： Munnamalai V,Fekete DM

更新日期：2013-05-01 00:00:00

abstract：:Since the first implication of the core planar cell polarity (PCP) pathway in stereocilia orientation of sensory hair cells in the mammalian cochlea, much has been written about this subject, in terms of understanding how this pathway can shape the mammalian hair cells and using the inner ear as a model system to unde...

journal_title：Seminars in cell & developmental biology

authors： Ezan J,Montcouquiol M

更新日期：2013-05-01 00:00:00

abstract：:The actin cytoskeleton is critically involved in a variety of cell functions. The Arp2/3 complex mediates branching of filamentous actin. The members of the Wiskott-Aldrich syndrome protein (WASP) family are major regulators of the complex. As such, the family proteins are also involved in numerous aspects of cell bio...

journal_title：Seminars in cell & developmental biology

authors： Oda A,Eto K

更新日期：2013-04-01 00:00:00